Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae

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Non-invasive imaging of disseminated candidiasis in zebrafish larvae.

Disseminated candidiasis caused by the pathogen Candida albicans is a clinically important problem in hospitalized individuals and is associated with a 30 to 40% attributable mortality(6). Systemic candidiasis is normally controlled by innate immunity, and individuals with genetic defects in innate immune cell components such as phagocyte NADPH oxidase are more susceptible to candidemia(7-9). V...

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Candida albicans is a human commensal and a clinically important fungal pathogen that grows in both yeast and hyphal forms during human infection. Although Candida can cause cutaneous and mucosal disease, systemic infections cause the greatest mortality in hospitals. Candidemia occurs primarily in immunocompromised patients, for whom the innate immune system plays a paramount role in immunity. ...

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ژورنال

عنوان ژورنال: Journal of Visualized Experiments

سال: 2012

ISSN: 1940-087X

DOI: 10.3791/4051